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The repressor protein, TetR, is a dimeric, DNA binding protein that regulates the expression of tetA and tetR at the level of transcription by binding in the absence of tetracycline to specific nucleotide sequences located within and overlapping the divergent promoter region (ie, tandem tet operators O1 and O2; eg, see Wissmann et al, (1991) Genetics 128:225-232). I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me.
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